Title |
Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
|
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Published in |
European Respiratory Journal, September 2018
|
DOI | 10.1183/13993003.00504-2018 |
Pubmed ID | |
Authors |
Zuelma A. Contreras, Zhanghua Chen, Theano Roumeliotaki, Isabella Annesi-Maesano, Nour Baïz, Andrea von Berg, Anna Bergström, Sarah Crozier, Liesbeth Duijts, Sandra Ekström, Esben Eller, Maria P. Fantini, Henrik Fomsgaard Kjaer, Francesco Forastiere, Beatrix Gerhard, Davide Gori, Margreet W. Harskamp-van Ginkel, Joachim Heinrich, Carmen Iñiguez, Hazel Inskip, Thomas Keil, Manolis Kogevinas, Susanne Lau, Irina Lehmann, Dieter Maier, Evelien R. van Meel, Monique Mommers, Mario Murcia, Daniela Porta, Henriëtte A. Smit, Marie Standl, Nikos Stratakis, Jordi Sunyer, Carel Thijs, Maties Torrent, Tanja G.M. Vrijkotte, Alet H. Wijga, Kiros Berhane, Frank Gilliland, Leda Chatzi |
Abstract |
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, and United Kingdom. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing, and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR): 1.66, 95% CI: 1.18, 2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma), exhibited a higher risk for obesity (aHR: 1.98, 95% CI: 1.31, 3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR: 1.51, 95% CI: 1.08, 2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 10 | 24% |
United States | 7 | 17% |
Spain | 6 | 14% |
Chile | 1 | 2% |
Canada | 1 | 2% |
France | 1 | 2% |
Algeria | 1 | 2% |
Greece | 1 | 2% |
Venezuela, Bolivarian Republic of | 1 | 2% |
Other | 1 | 2% |
Unknown | 12 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 29 | 69% |
Scientists | 8 | 19% |
Practitioners (doctors, other healthcare professionals) | 4 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 118 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 15 | 13% |
Researcher | 12 | 10% |
Student > Master | 12 | 10% |
Student > Ph. D. Student | 11 | 9% |
Student > Postgraduate | 9 | 8% |
Other | 16 | 14% |
Unknown | 43 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 23% |
Nursing and Health Professions | 15 | 13% |
Environmental Science | 4 | 3% |
Social Sciences | 3 | 3% |
Sports and Recreations | 3 | 3% |
Other | 18 | 15% |
Unknown | 48 | 41% |