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Mendeley readers
| Title |
Treadmill exercise improves short-term memory by enhancing neurogenesis in amyloid beta-induced Alzheimer disease rats
|
|---|---|
| Published in |
Journal of Exercise Rehabilitation, February 2014
|
| DOI | 10.12965/jer.140086 |
| Pubmed ID | |
| Authors |
Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Sang-Bin Baek, Yeong-Chan Ko, Young-Pyo Kim |
| Abstract |
Alzheimer's disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impairment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise on short-term memory in relation with neurogenesis in the rats with amyloid β25-35 (Aβ25-35)-induced Alzheimer's disease. The rat model of Alzheimer's disease was induced by the intracerebroventricular (ICV) injection of Aβ25-35, using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 4 consecutive weeks, starting 2 days after Aβ25-35 injection. Presently, short-term memory was deteriorated and apical dendritic length in the hippocampus was shortened in the hippocampus by Aβ25-35 injection. In contrast, treadmill exercise alleviated memory impairment and increased apical dendritic length in the Aβ25-35-injected rats. Neurogenesis and brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (trkB) in the hippocampal dentate gyrus were decreased by Aβ25-35 injection. Treadmill exercise increased neurogenesis and expressions of BDNF and trkB expressions. The present study shows that treadmill exercise may provide therapeutic value for the alleviating symptoms of Alzheimer's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 127 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 34 | 26% |
| Student > Ph. D. Student | 17 | 13% |
| Student > Master | 13 | 10% |
| Researcher | 12 | 9% |
| Student > Doctoral Student | 8 | 6% |
| Other | 15 | 12% |
| Unknown | 30 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 18% |
| Neuroscience | 23 | 18% |
| Medicine and Dentistry | 15 | 12% |
| Nursing and Health Professions | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Other | 21 | 16% |
| Unknown | 35 | 27% |