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Mendeley readers
Attention Score in Context
| Title |
Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection
|
|---|---|
| Published in |
PLoS Pathogens, February 2010
|
| DOI | 10.1371/journal.ppat.1000778 |
| Pubmed ID | |
| Authors |
Jamel Mankouri, Rennos Fragkoudis, Kathryn H. Richards, Laura F. Wetherill, Mark Harris, Alain Kohl, Richard M. Elliott, Andrew Macdonald |
| Abstract |
The innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases (RLHs). Detection of virus triggers signalling cascades that induce transcription of type I interferons including IFNbeta, which are pivotal for the initiation of an anti-viral state. Despite the essential role of IFNbeta in the anti-viral response, there is an incomplete understanding of the negative regulation of IFNbeta induction. Here we provide evidence that expression of the Nemo-related protein, optineurin (NRP/FIP2), has a role in the inhibition of virus-triggered IFNbeta induction. Over-expression of optineurin inhibited Sendai-virus (SeV) and dsRNA triggered induction of IFNbeta, whereas depletion of optineurin with siRNA promoted virus-induced IFNbeta production and decreased RNA virus replication. Immunoprecipitation and immunofluorescence studies identified optineurin in a protein complex containing the antiviral protein kinase TBK1 and the ubiquitin ligase TRAF3. Furthermore, mutagenesis studies determined that binding of ubiquitin was essential for both the correct sub-cellular localisation and the inhibitory function of optineurin. This work identifies optineurin as a critical regulator of antiviral signalling and potential target for future antiviral therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 99 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 25% |
| Student > Ph. D. Student | 22 | 22% |
| Student > Master | 12 | 12% |
| Professor > Associate Professor | 6 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 18 | 18% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 46 | 45% |
| Biochemistry, Genetics and Molecular Biology | 12 | 12% |
| Medicine and Dentistry | 12 | 12% |
| Immunology and Microbiology | 11 | 11% |
| Neuroscience | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 12 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2010.
All research outputs
#17,649,940
of 25,870,940 outputs
Outputs from PLoS Pathogens
#8,045
of 9,571 outputs
Outputs of similar age
#87,089
of 104,825 outputs
Outputs of similar age from PLoS Pathogens
#67
of 86 outputs
Altmetric has tracked 25,870,940 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,571 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,825 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.