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The Correlations among Depressive Symptoms, Cognitive Performance and Serum BDNF Levels in the Patients with Chronic Kidney Disease

Overview of attention for article published in Psychiatry Investigation, October 2017
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Title
The Correlations among Depressive Symptoms, Cognitive Performance and Serum BDNF Levels in the Patients with Chronic Kidney Disease
Published in
Psychiatry Investigation, October 2017
DOI 10.30773/pi.2017.03.09
Pubmed ID
Authors

Jung Goo Lee, Min Kyung Park, Yeong Hoon Kim, Yang-Wook Kim, Kyubok Jin, Sung Woo Park, Mi Kyoung Seo, Young Hoon Kim

Abstract

In the current study, we investigated whether there are relations among depressive symptoms, cognitive performance and serum BDNF levels in the patients with chronic kidney disease (CKD). Sixty patients with CKD and 65 healthy controls participated. Depressive symptoms were evaluated with Beck depression inventory (BDI) and Hamilton Depression Rating Scale (HDRS). Mini-Mental State Examination included in the Korean version of the Consortium to Establish a Registry for Alzheimer's disease (MMSE-KC) assessment packet was used for the evaluation of overall cognitive function. To assess memory function, the Korean version of the Hopkins Verbal Learning Test (K-HVLT) was used. BDNF levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit. The CKD patients showed more depressive symptoms when compared with controls. The depressive symptoms and cognitive function were not associated with serum BDNF levels in the CKD patients. In the current study, CKD patients had more depressive symptoms when compared controls. However, the serum BDNF levels of CKD patients were not associated with depressive symptoms and cognitive functions. These findings suggested that the serum BDNF levels may not be reflect the cognitive function and depressive mood state in the CKD patients.

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Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 15%
Student > Bachelor 4 12%
Student > Ph. D. Student 3 9%
Student > Master 3 9%
Student > Doctoral Student 2 6%
Other 5 15%
Unknown 12 35%
Readers by discipline Count As %
Medicine and Dentistry 6 18%
Psychology 3 9%
Neuroscience 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Sports and Recreations 1 3%
Other 2 6%
Unknown 17 50%