Title |
Can the Natural Diversity of Quorum-Sensing Advance Synthetic Biology?
|
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Published in |
Frontiers in Bioengineering and Biotechnology, March 2015
|
DOI | 10.3389/fbioe.2015.00030 |
Pubmed ID | |
Authors |
René Michele Davis, Ryan Yue Muller, Karmella Ann Haynes |
Abstract |
Quorum-sensing networks enable bacteria to sense and respond to chemical signals produced by neighboring bacteria. They are widespread: over 100 morphologically and genetically distinct species of eubacteria are known to use quorum sensing to control gene expression. This diversity suggests the potential to use natural protein variants to engineer parallel, input-specific, cell-cell communication pathways. However, only three distinct signaling pathways, Lux, Las, and Rhl, have been adapted for and broadly used in engineered systems. The paucity of unique quorum-sensing systems and their propensity for crosstalk limits the usefulness of our current quorum-sensing toolkit. This review discusses the need for more signaling pathways, roadblocks to using multiple pathways in parallel, and strategies for expanding the quorum-sensing toolbox for synthetic biology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 21% |
Switzerland | 1 | 7% |
Canada | 1 | 7% |
Spain | 1 | 7% |
Unknown | 8 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 79% |
Scientists | 2 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Spain | 2 | 1% |
United States | 1 | <1% |
China | 1 | <1% |
Unknown | 153 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 22% |
Student > Master | 25 | 16% |
Student > Bachelor | 22 | 14% |
Researcher | 19 | 12% |
Student > Doctoral Student | 12 | 8% |
Other | 21 | 13% |
Unknown | 25 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 45 | 28% |
Agricultural and Biological Sciences | 44 | 28% |
Engineering | 13 | 8% |
Medicine and Dentistry | 5 | 3% |
Chemistry | 5 | 3% |
Other | 16 | 10% |
Unknown | 31 | 19% |