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SPECTRA: An Integrated Knowledge Base for Comparing Tissue and Tumor-Specific PPI Networks in Human

Overview of attention for article published in Frontiers in Bioengineering and Biotechnology, May 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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1 blog
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2 X users

Citations

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13 Dimensions

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30 Mendeley
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Title
SPECTRA: An Integrated Knowledge Base for Comparing Tissue and Tumor-Specific PPI Networks in Human
Published in
Frontiers in Bioengineering and Biotechnology, May 2015
DOI 10.3389/fbioe.2015.00058
Pubmed ID
Authors

Giovanni Micale, Alfredo Ferro, Alfredo Pulvirenti, Rosalba Giugno

Abstract

Protein-protein interaction (PPI) networks available in public repositories usually represent relationships between proteins within the cell. They ignore the specific set of tissues or tumors where the interactions take place. Indeed, proteins can form tissue-selective complexes, while they remain inactive in other tissues. For these reasons, a great attention has been recently paid to tissue-specific PPI networks, in which nodes are proteins of the global PPI network whose corresponding genes are preferentially expressed in specific tissues. In this paper, we present SPECTRA, a knowledge base to build and compare tissue or tumor-specific PPI networks. SPECTRA integrates gene expression and protein interaction data from the most authoritative online repositories. We also provide tools for visualizing and comparing such networks, in order to identify the expression and interaction changes of proteins across tissues, or between the normal and pathological states of the same tissue. SPECTRA is available as a web server at http://alpha.dmi.unict.it/spectra.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 33%
Researcher 6 20%
Student > Master 5 17%
Student > Bachelor 2 7%
Professor 1 3%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Computer Science 7 23%
Biochemistry, Genetics and Molecular Biology 6 20%
Medicine and Dentistry 3 10%
Mathematics 2 7%
Other 0 0%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2015.
All research outputs
#3,535,523
of 25,373,627 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#482
of 8,500 outputs
Outputs of similar age
#43,947
of 279,154 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#6
of 54 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,500 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,154 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.