3D Printing of Octacalcium Phosphate Bone Substitutes

Vladimir S. Komlev, Vladimir K. Popov, Anton V. Mironov, Alexander Yu. Fedotov, Anastasia Yu. Teterina, Igor V. Smirnov, Ilya Y. Bozo, Vera A. Rybko, Roman V. Deev

Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual complex bone substitutes. Here, we proposed a relatively simple route for 3D printing of octacalcium phosphates (OCP) in complexly shaped structures by the combination of inkjet printing with post-treatment methodology. The printed OCP blocks were further implanted in the developed cranial bone defect followed by histological evaluation. The obtained result confirmed the potential of the developed OCP bone substitutes, which allowed 2.5-time reducing of defect's diameter at 6.5 months in a region where native bone repair is extremely inefficient.