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A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles

Overview of attention for article published in Frontiers in Bioengineering and Biotechnology, September 2015
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Title
A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles
Published in
Frontiers in Bioengineering and Biotechnology, September 2015
DOI 10.3389/fbioe.2015.00140
Pubmed ID
Authors

Choi, Young Joon, Constantino, Jason, Vedula, Vijay, Trayanova, Natalia, Mittal, Rajat

Abstract

A methodology for the simulation of heart function that combines an MRI-based model of cardiac electromechanics (CE) with a Navier-Stokes-based hemodynamics model is presented. The CE model consists of two coupled components that simulate the electrical and the mechanical functions of the heart. Accurate representations of ventricular geometry and fiber orientations are constructed from the structural magnetic resonance and the diffusion tensor MR images, respectively. The deformation of the ventricle obtained from the electromechanical model serves as input to the hemodynamics model in this one-way coupled approach via imposed kinematic wall velocity boundary conditions and at the same time, governs the blood flow into and out of the ventricular volume. The time-dependent endocardial surfaces are registered using a diffeomorphic mapping algorithm, while the intraventricular blood flow patterns are simulated using a sharp-interface immersed boundary method-based flow solver. The utility of the combined heart-function model is demonstrated by comparing the hemodynamic characteristics of a normal canine heart beating in sinus rhythm against that of the dyssynchronously beating failing heart. We also discuss the potential of coupled CE and hemodynamics models for various clinical applications.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
United Kingdom 1 2%
Norway 1 2%
Canada 1 2%
Unknown 42 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 30%
Professor > Associate Professor 5 11%
Student > Ph. D. Student 5 11%
Student > Bachelor 4 9%
Other 4 9%
Other 5 11%
Unknown 10 21%
Readers by discipline Count As %
Engineering 18 38%
Medicine and Dentistry 5 11%
Mathematics 3 6%
Computer Science 2 4%
Chemical Engineering 1 2%
Other 2 4%
Unknown 16 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2015.
All research outputs
#18,427,608
of 22,829,083 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#3,396
of 6,561 outputs
Outputs of similar age
#197,744
of 274,809 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#43
of 63 outputs
Altmetric has tracked 22,829,083 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,561 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.