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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterizing Glioblastoma Heterogeneity via Single-Cell Receptor Quantification
|
|---|---|
| Published in |
Frontiers in Bioengineering and Biotechnology, July 2018
|
| DOI | 10.3389/fbioe.2018.00092 |
| Pubmed ID | |
| Authors |
Si Chen, Thien Le, Brendan A. C. Harley, P. I. Imoukhuede |
| Abstract |
Dysregulation of tyrosine kinase receptor (RTK) signaling pathways play important roles in glioblastoma (GBM). However, therapies targeting these signaling pathways have not been successful, partially because of drug resistance. Increasing evidence suggests that tumor heterogeneity, more specifically, GBM-associated stem and endothelial cell heterogeneity, may contribute to drug resistance. In this perspective article, we introduce a high-throughput, quantitative approach to profile plasma membrane RTKs on single cells. First, we review the roles of RTKs in cancer. Then, we discuss the sources of cell heterogeneity in GBM, providing context to the key cells directing resistance to drugs. Finally, we present our provisionally patented qFlow cytometry approach, and report results of a "proof of concept" patient-derived xenograft GBM study. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 50% |
| Italy | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 34% |
| Researcher | 10 | 15% |
| Student > Master | 8 | 12% |
| Student > Bachelor | 5 | 7% |
| Student > Doctoral Student | 4 | 6% |
| Other | 5 | 7% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 21% |
| Engineering | 9 | 13% |
| Medicine and Dentistry | 7 | 10% |
| Agricultural and Biological Sciences | 7 | 10% |
| Chemistry | 5 | 7% |
| Other | 10 | 15% |
| Unknown | 15 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2022.
All research outputs
#6,308,601
of 23,122,481 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#924
of 6,807 outputs
Outputs of similar age
#108,607
of 326,825 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#20
of 48 outputs
Altmetric has tracked 23,122,481 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 6,807 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,825 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.