Title |
HMGA proteins as modulators of chromatin structure during transcriptional activation
|
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Published in |
Frontiers in Cell and Developmental Biology, March 2014
|
DOI | 10.3389/fcell.2014.00005 |
Pubmed ID | |
Authors |
Nihan Ozturk, Indrabahadur Singh, Aditi Mehta, Thomas Braun, Guillermo Barreto |
Abstract |
High mobility group (HMG) proteins are the most abundant non-histone chromatin associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of chromatin locally and globally. Accessibility to DNA within chromatin is a central factor that affects DNA-dependent nuclear processes, such as transcription, replication, recombination, and repair. HMG proteins associate with different multi-protein complexes to regulate these processes by mediating accessibility to DNA. HMG proteins can be subdivided into three families: HMGA, HMGB, and HMGN. In this review, we will focus on recent advances in understanding the function of HMGA family members, specifically their role in gene transcription regulation during development and cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Serbia | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 127 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 23% |
Student > Master | 20 | 16% |
Researcher | 14 | 11% |
Student > Bachelor | 13 | 10% |
Student > Doctoral Student | 13 | 10% |
Other | 13 | 10% |
Unknown | 26 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 49 | 38% |
Agricultural and Biological Sciences | 28 | 22% |
Medicine and Dentistry | 12 | 9% |
Chemistry | 2 | 2% |
Immunology and Microbiology | 2 | 2% |
Other | 7 | 5% |
Unknown | 29 | 22% |