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Mendeley readers
Attention Score in Context
| Title |
The antigenic determinant that defines thymic nurse cells is expressed by thymic epithelial progenitor cells
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, April 2014
|
| DOI | 10.3389/fcell.2014.00013 |
| Pubmed ID | |
| Authors |
Rajendra V. E. Chilukuri, Viral K. Patel, Marcia Martinez, Jerry C. Guyden, Michael D. Samms |
| Abstract |
Stromal thymic epithelial cells with the multicellular structure unique to thymic nurse cells (TNCs) express the pH91 antigen on their cell surfaces. The multicellular TNC-complexes develop through an intimate association between αβTCR(+)CD4(+)CD8(+) thymocytes and pH91-expressing cortical epithelial cells. TNCs participate in MHC-restriction and exhibit epithelial cell progenitor characteristics. In this report, we show that as early as E11.5 stage of thymus development, the pH91 antigen is expressed in association with K8, K5, Foxn1 and p63. The expression of these epithelial progenitor markers along with the pH91 antigen persists throughout thymic development in the murine thymus. At E13.5, pH91(+) cells express relatively low levels of MHC class II. After E17.5, the first multicellular TNC complexes are recognizable along with increased cell surface expression of MHC class II. Our data suggest that epithelial cells bearing the "progenitor phenotype" develop into the multicellular TNCs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 50% |
| Student > Ph. D. Student | 3 | 30% |
| Student > Bachelor | 1 | 10% |
| Student > Master | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 90% |
| Immunology and Microbiology | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2016.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Frontiers in Cell and Developmental Biology
#5,727
of 10,472 outputs
Outputs of similar age
#178,308
of 242,066 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#13
of 20 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,472 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.