Title |
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, January 2016
|
DOI | 10.3389/fcell.2015.00085 |
Pubmed ID | |
Authors |
Olivia B. Parks, Derek A. Pociask, Zerina Hodzic, Jay K. Kolls, Misty Good |
Abstract |
Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | <1% |
Unknown | 233 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 54 | 23% |
Researcher | 34 | 15% |
Student > Master | 32 | 14% |
Student > Bachelor | 29 | 12% |
Student > Doctoral Student | 14 | 6% |
Other | 30 | 13% |
Unknown | 41 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 57 | 24% |
Biochemistry, Genetics and Molecular Biology | 42 | 18% |
Agricultural and Biological Sciences | 41 | 18% |
Medicine and Dentistry | 21 | 9% |
Neuroscience | 6 | 3% |
Other | 20 | 9% |
Unknown | 47 | 20% |