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Membrane Tethering Complexes in the Endosomal System

Overview of attention for article published in Frontiers in Cell and Developmental Biology, May 2016
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Title
Membrane Tethering Complexes in the Endosomal System
Published in
Frontiers in Cell and Developmental Biology, May 2016
DOI 10.3389/fcell.2016.00035
Pubmed ID
Authors

Anne Spang

Abstract

Vesicles that are generated by endocytic events at the plasma membrane are destined to early endosomes. A prerequisite for proper fusion is the tethering of two membrane entities. Tethering of vesicles to early endosomes is mediated by the class C core vacuole/endosome tethering (CORVET) complex, while fusion of late endosomes with lysosomes depends on the homotypic fusion and vacuole protein sorting (HOPS) complex. Recycling through the trans-Golgi network (TGN) and to the plasma membrane is facilitated by the Golgi associated retrograde protein (GARP) and endosome-associated recycling protein (EARP) complexes, respectively. However, there are other tethering functions in the endosomal system as there are multiple pathways through which proteins can be delivered from endosomes to either the TGN or the plasma membrane. Furthermore, proteins that may be part of novel tethering complexes have been recently identified. Thus, it is likely that more tethering factors exist. In this review, I will provide an overview of different tethering complexes of the endosomal system and discuss how they may provide specificity in membrane traffic.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Unknown 205 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 27%
Researcher 28 14%
Student > Bachelor 23 11%
Student > Master 22 11%
Student > Doctoral Student 17 8%
Other 23 11%
Unknown 39 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 85 41%
Agricultural and Biological Sciences 51 25%
Immunology and Microbiology 8 4%
Neuroscience 8 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 11 5%
Unknown 39 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#15,372,369
of 22,869,263 outputs
Outputs from Frontiers in Cell and Developmental Biology
#3,978
of 9,042 outputs
Outputs of similar age
#181,590
of 301,827 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#27
of 45 outputs
Altmetric has tracked 22,869,263 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,042 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,827 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.