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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CNS Remyelination and the Innate Immune System
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, May 2016
|
| DOI | 10.3389/fcell.2016.00038 |
| Pubmed ID | |
| Authors |
Christopher E. McMurran, Clare A. Jones, Denise C. Fitzgerald, Robin J. M. Franklin |
| Abstract |
A misguided inflammatory response is frequently implicated in myelin damage. Particularly prominent among myelin diseases, multiple sclerosis (MS) is an autoimmune condition, with immune-mediated damage central to its etiology. Nevertheless, a robust inflammatory response is also essential for the efficient regeneration of myelin sheaths after such injury. Here, we discuss the functions of inflammation that promote remyelination, and how these have been experimentally disentangled from the pathological facets of the immune response. We focus on the contributions that resident microglia and monocyte-derived macrophages make to remyelination and compare the roles of these two populations of innate immune cells. Finally, the current literature is framed in the context of developing therapies that manipulate the innate immune response to promote remyelination in clinical myelin disease. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 131 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 20% |
| Researcher | 23 | 17% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 13 | 10% |
| Student > Doctoral Student | 10 | 8% |
| Other | 18 | 14% |
| Unknown | 28 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 34 | 26% |
| Agricultural and Biological Sciences | 21 | 16% |
| Medicine and Dentistry | 15 | 11% |
| Biochemistry, Genetics and Molecular Biology | 12 | 9% |
| Immunology and Microbiology | 9 | 7% |
| Other | 11 | 8% |
| Unknown | 30 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2016.
All research outputs
#12,923,528
of 23,299,593 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,994
of 9,286 outputs
Outputs of similar age
#134,401
of 299,829 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#12
of 42 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,286 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.