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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, September 2016
|
| DOI | 10.3389/fcell.2016.00107 |
| Pubmed ID | |
| Authors |
Daniel Torralba, Francesc Baixauli, Francisco Sánchez-Madrid |
| Abstract |
Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although, the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance in vitro and in vivo. In this review, we outline the pathophysiological consequences of horizontal mitochondrial transfer and offer a perspective on the cellular and molecular mechanisms mediating their intercellular transmission, including tunneling nanotubes, extracellular vesicles, cellular fusion, and GAP junctions. The physiological relevance of mitochondrial transfer and the potential therapeutic application of this exchange for treating mitochondrial-related diseases are discussed. |
X Demographics
The data shown below were collected from the profiles of 65 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 15 | 23% |
| United States | 9 | 14% |
| Canada | 4 | 6% |
| Ireland | 2 | 3% |
| Norway | 2 | 3% |
| Argentina | 1 | 2% |
| Latvia | 1 | 2% |
| Sweden | 1 | 2% |
| Switzerland | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 28 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 46 | 71% |
| Practitioners (doctors, other healthcare professionals) | 11 | 17% |
| Scientists | 6 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 449 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | <1% |
| Unknown | 448 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 92 | 20% |
| Researcher | 60 | 13% |
| Student > Bachelor | 57 | 13% |
| Student > Master | 47 | 10% |
| Student > Doctoral Student | 27 | 6% |
| Other | 57 | 13% |
| Unknown | 109 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 130 | 29% |
| Agricultural and Biological Sciences | 61 | 14% |
| Neuroscience | 33 | 7% |
| Medicine and Dentistry | 32 | 7% |
| Immunology and Microbiology | 15 | 3% |
| Other | 47 | 10% |
| Unknown | 131 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2023.
All research outputs
#581,095
of 25,670,640 outputs
Outputs from Frontiers in Cell and Developmental Biology
#56
of 10,579 outputs
Outputs of similar age
#10,973
of 331,202 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#1
of 46 outputs
Altmetric has tracked 25,670,640 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,579 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,202 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.