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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, January 2017
|
| DOI | 10.3389/fcell.2017.00001 |
| Pubmed ID | |
| Authors |
Ekta Khattar, Vinay Tergaonkar |
| Abstract |
Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase reverse transcriptase (TERT), the catalytic component of telomerase. Transcription factor binding, chromatin status as well as epigenetic modifications at the TERT promoter regulates TERT transcription. Myc is an important transcriptional regulator of TERT that directly controls its expression by promoter binding and associating with other transcription factors. In this review, we discuss the current understanding of the molecular mechanisms behind regulation of TERT transcription by Myc. We also discuss future perspectives in investigating the regulation of Myc at TERT promoter during cancer development. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 24% |
| Student > Ph. D. Student | 12 | 17% |
| Researcher | 7 | 10% |
| Student > Master | 6 | 9% |
| Other | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 43% |
| Medicine and Dentistry | 7 | 10% |
| Agricultural and Biological Sciences | 5 | 7% |
| Engineering | 2 | 3% |
| Neuroscience | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2017.
All research outputs
#15,437,553
of 22,947,506 outputs
Outputs from Frontiers in Cell and Developmental Biology
#3,996
of 9,089 outputs
Outputs of similar age
#255,918
of 418,939 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#21
of 35 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,089 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 418,939 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.