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PBX1 as Pioneer Factor: A Case Still Open

Overview of attention for article published in Frontiers in Cell and Developmental Biology, February 2017
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Title
PBX1 as Pioneer Factor: A Case Still Open
Published in
Frontiers in Cell and Developmental Biology, February 2017
DOI 10.3389/fcell.2017.00009
Pubmed ID
Authors

Britta M. Grebbin, Dorothea Schulte

Abstract

Pioneer factors are proteins that can recognize their target sites in barely accessible chromatin and initiate a cascade of events that allows for later transcriptional activation of the respective genes. Pioneer factors are therefore particularly well-suited to initiate cell fate changes. To date, only a small number of pioneer factors have been identified and studied in depth, such as FOXD3/FOXA1, OCT4, or SOX2. Interestingly, several recent studies reported that the PBC transcription factor PBX1 can access transcriptionally inactive genomic loci. Here, we summarize the evidence linking PBX1 with transcriptional pioneer functions, suggest potential mechanisms involved and discuss open questions to be resolved.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 55 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 20%
Student > Bachelor 10 18%
Student > Ph. D. Student 10 18%
Researcher 8 14%
Student > Doctoral Student 6 11%
Other 4 7%
Unknown 7 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 38%
Agricultural and Biological Sciences 15 27%
Neuroscience 3 5%
Medicine and Dentistry 3 5%
Economics, Econometrics and Finance 1 2%
Other 2 4%
Unknown 11 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2017.
All research outputs
#15,443,875
of 22,953,506 outputs
Outputs from Frontiers in Cell and Developmental Biology
#3,994
of 9,092 outputs
Outputs of similar age
#261,141
of 428,391 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#21
of 35 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,092 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 428,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.