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Implications for a Stem Cell Regenerative Medicine Based Approach to Human Intervertebral Disk Degeneration

Overview of attention for article published in Frontiers in Cell and Developmental Biology, March 2017
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Title
Implications for a Stem Cell Regenerative Medicine Based Approach to Human Intervertebral Disk Degeneration
Published in
Frontiers in Cell and Developmental Biology, March 2017
DOI 10.3389/fcell.2017.00017
Pubmed ID
Authors

Petra Kraus, Thomas Lufkin

Abstract

The human body develops from a single cell, the zygote, the product of the maternal oocyte and the paternal spermatozoon. That 1-cell zygote embryo will divide and eventually grow into an adult human which is comprised of ~3.7 × 10(13) cells. The tens of trillions of cells in the adult human can be classified into approximately 200 different highly specialized cell types that make up all of the different tissues and organs of the human body. Regenerative medicine aims to replace or restore dysfunctional cells, tissues and organs with fully functional ones. One area receiving attention is regeneration of the intervertebral discs (IVDs), which are located between the vertebrae and function to give flexibility and support load to the spine. Degenerated discs are a major cause of lower back pain. Different stem cell based regenerative medicine approaches to cure disc degeneration are now available, including using autologous mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs) and even attempts at direct transdifferentiation of somatic cells. Here we discuss some of the recent advances, successes, drawbacks, and the failures of the above-mentioned approaches.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Student > Master 8 17%
Student > Bachelor 7 15%
Professor > Associate Professor 5 11%
Student > Doctoral Student 4 9%
Other 6 13%
Unknown 7 15%
Readers by discipline Count As %
Medicine and Dentistry 18 39%
Engineering 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 2 4%
Other 4 9%
Unknown 12 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2017.
All research outputs
#14,336,352
of 22,958,253 outputs
Outputs from Frontiers in Cell and Developmental Biology
#2,851
of 9,091 outputs
Outputs of similar age
#174,097
of 307,995 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#21
of 39 outputs
Altmetric has tracked 22,958,253 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,091 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,995 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.