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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Bioengineering Approaches to Mature Human Pluripotent Stem Cell-Derived Cardiomyocytes
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, March 2017
|
| DOI | 10.3389/fcell.2017.00019 |
| Pubmed ID | |
| Authors |
Xuetao Sun, Sara S. Nunes |
| Abstract |
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) represent a potential unlimited cell supply for cardiac tissue engineering and possibly regenerative medicine applications. However, hPSC-CMs produced by current protocols are not representative of native adult human cardiomyocytes as they display immature gene expression profile, structure and function. In order to improve hPSC-CM maturity and function, various approaches have been developed, including genetic manipulations to induce gene expression, delivery of biochemical factors, such as triiodothyronine and alpha-adrenergic agonist phenylephrine, induction of cell alignment in 3D tissues, mechanical stress as a mimic of cardiac load and electrical stimulation/pacing or a combination of these. In this mini review, we discuss biomimetic strategies for the maturation for hPSC-CMs with a particular focus on electromechanical conditioning methods. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 67% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 103 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 19% |
| Student > Bachelor | 17 | 17% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 8 | 8% |
| Student > Postgraduate | 7 | 7% |
| Other | 12 | 12% |
| Unknown | 30 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 23% |
| Engineering | 16 | 16% |
| Agricultural and Biological Sciences | 15 | 15% |
| Medicine and Dentistry | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 12 | 12% |
| Unknown | 29 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2017.
All research outputs
#13,192,260
of 22,958,253 outputs
Outputs from Frontiers in Cell and Developmental Biology
#2,139
of 9,091 outputs
Outputs of similar age
#153,275
of 307,900 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#14
of 39 outputs
Altmetric has tracked 22,958,253 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,091 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,900 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.