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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tetraspanins Function as Regulators of Cellular Signaling
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, April 2017
|
| DOI | 10.3389/fcell.2017.00034 |
| Pubmed ID | |
| Authors |
Christina M. Termini, Jennifer M. Gillette |
| Abstract |
Tetraspanins are molecular scaffolds that distribute proteins into highly organized microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have identified interactions between tetraspanins and signaling molecules, finding unique downstream cellular consequences. In this review, we will explore these interactions as well as the specific cellular responses to signal activation, focusing on tetraspanin regulation of adhesion-mediated (integrins/FAK), receptor-mediated (EGFR, TNF-α, c-Met, c-Kit), and intracellular signaling (PKC, PI4K, β-catenin). Additionally, we will summarize our current understanding for how tetraspanin post-translational modifications (palmitoylation, N-linked glycosylation, and ubiquitination) can regulate signal propagation. Many of the studies outlined in this review suggest that tetraspanins offer a potential therapeutic target to modulate aberrant signal transduction pathways that directly impact a host of cellular behaviors and disease states. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 333 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 23% |
| Student > Bachelor | 47 | 14% |
| Researcher | 41 | 12% |
| Student > Master | 40 | 12% |
| Student > Doctoral Student | 19 | 6% |
| Other | 32 | 10% |
| Unknown | 77 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 116 | 35% |
| Agricultural and Biological Sciences | 45 | 14% |
| Immunology and Microbiology | 25 | 8% |
| Medicine and Dentistry | 22 | 7% |
| Neuroscience | 9 | 3% |
| Other | 28 | 8% |
| Unknown | 88 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2023.
All research outputs
#7,499,697
of 24,654,416 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,783
of 10,082 outputs
Outputs of similar age
#111,359
of 314,087 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#17
of 46 outputs
Altmetric has tracked 24,654,416 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 10,082 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.