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Pulmonary Extracellular Vesicles as Mediators of Local and Systemic Inflammation

Overview of attention for article published in Frontiers in Cell and Developmental Biology, April 2017
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Title
Pulmonary Extracellular Vesicles as Mediators of Local and Systemic Inflammation
Published in
Frontiers in Cell and Developmental Biology, April 2017
DOI 10.3389/fcell.2017.00039
Pubmed ID
Authors

Casper J. E. Wahlund, Anders Eklund, Johan Grunewald, Susanne Gabrielsson

Abstract

Cells of the airways are constantly exposed to environmental hazards including cigarette smoke, irritants, pathogens, and mechanical insults. Maintaining barrier integrity is vital, and mounting responses to threats depends on intercellular communication. Extracellular vesicles (EVs), including exosomes and microvesicles, are major signal mediators between cells, shuttling cargo in health and disease. Depending on the state of the originating cells, EVs are capable of inducing proinflammatory effects including antigen presentation, cellular migration, apoptosis induction, and inflammatory cytokine release. Cells of the airways release EVs, which can be found in bronchoalveolar lavage fluid. EVs of the airways can support inflammation in the lung, but may also exit into the circulation and carry a cocktail of pro-inflammatory molecules to recipient cells in distant organs. In this review, we discuss the possibility that EVs originating from the airways contribute to dissemination of inflammation in both lung disorders and systemic inflammatory conditions.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 92 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 23%
Student > Doctoral Student 12 13%
Student > Master 10 11%
Researcher 8 9%
Other 6 6%
Other 16 17%
Unknown 20 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 19%
Medicine and Dentistry 18 19%
Nursing and Health Professions 7 8%
Engineering 6 6%
Immunology and Microbiology 6 6%
Other 16 17%
Unknown 22 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2017.
All research outputs
#20,705,128
of 23,305,591 outputs
Outputs from Frontiers in Cell and Developmental Biology
#6,230
of 9,291 outputs
Outputs of similar age
#270,377
of 310,627 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#42
of 42 outputs
Altmetric has tracked 23,305,591 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,291 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,627 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.