Title |
Interorganelle Communication between Mitochondria and the Endolysosomal System
|
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Published in |
Frontiers in Cell and Developmental Biology, November 2017
|
DOI | 10.3389/fcell.2017.00095 |
Pubmed ID | |
Authors |
Gonzalo Soto-Heredero, Francesc Baixauli, María Mittelbrunn |
Abstract |
The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 29% |
Netherlands | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 154 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 21% |
Researcher | 21 | 14% |
Student > Bachelor | 21 | 14% |
Student > Master | 13 | 8% |
Student > Doctoral Student | 10 | 6% |
Other | 19 | 12% |
Unknown | 37 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 49 | 32% |
Agricultural and Biological Sciences | 26 | 17% |
Neuroscience | 11 | 7% |
Medicine and Dentistry | 9 | 6% |
Immunology and Microbiology | 8 | 5% |
Other | 9 | 6% |
Unknown | 42 | 27% |