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RUNX1 Mutations in Inherited and Sporadic Leukemia

Overview of attention for article published in Frontiers in Cell and Developmental Biology, December 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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Title
RUNX1 Mutations in Inherited and Sporadic Leukemia
Published in
Frontiers in Cell and Developmental Biology, December 2017
DOI 10.3389/fcell.2017.00111
Pubmed ID
Authors

Dana C. Bellissimo, Nancy A. Speck

Abstract

RUNX1 is a recurrently mutated gene in sporadic myelodysplastic syndrome and leukemia. Inherited mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). In sporadic AML, mutations in RUNX1 are usually secondary events, whereas in FPD/AML they are initiating events. Here we will describe mutations in RUNX1 in sporadic AML and in FPD/AML, discuss the mechanisms by which inherited mutations in RUNX1 could elevate the risk of AML in FPD/AML individuals, and speculate on why mutations in RUNX1 are rarely, if ever, the first event in sporadic AML.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 81 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 21%
Researcher 14 17%
Student > Postgraduate 9 11%
Student > Bachelor 9 11%
Student > Master 5 6%
Other 7 9%
Unknown 20 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 32%
Medicine and Dentistry 15 19%
Agricultural and Biological Sciences 9 11%
Immunology and Microbiology 3 4%
Unspecified 1 1%
Other 2 2%
Unknown 25 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2018.
All research outputs
#12,766,410
of 23,012,811 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,924
of 9,115 outputs
Outputs of similar age
#197,944
of 440,645 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#7
of 28 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,115 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,645 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.