Title |
What We Learned From Big Data for Autophagy Research
|
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Published in |
Frontiers in Cell and Developmental Biology, August 2018
|
DOI | 10.3389/fcell.2018.00092 |
Pubmed ID | |
Authors |
Anne-Claire Jacomin, Lejla Gul, Padhmanand Sudhakar, Tamas Korcsmaros, Ioannis P. Nezis |
Abstract |
Autophagy is the process by which cytoplasmic components are engulfed in double-membraned vesicles before being delivered to the lysosome to be degraded. Defective autophagy has been linked to a vast array of human pathologies. The molecular mechanism of the autophagic machinery is well-described and has been extensively investigated. However, understanding the global organization of the autophagy system and its integration with other cellular processes remains a challenge. To this end, various bioinformatics and network biology approaches have been developed by researchers in the last few years. Recently, large-scale multi-omics approaches (like genomics, transcriptomics, proteomics, lipidomics, and metabolomics) have been developed and carried out specifically focusing on autophagy, and generating multi-scale data on the related components. In this review, we outline recent applications of in silico investigations and big data analyses of the autophagy process in various biological systems. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 5 | 14% |
United States | 4 | 11% |
Canada | 3 | 8% |
Spain | 2 | 5% |
Chile | 2 | 5% |
Austria | 1 | 3% |
Hungary | 1 | 3% |
Japan | 1 | 3% |
Germany | 1 | 3% |
Other | 1 | 3% |
Unknown | 16 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 19 | 51% |
Scientists | 18 | 49% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 21% |
Student > Ph. D. Student | 14 | 15% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 7 | 8% |
Student > Master | 6 | 7% |
Other | 14 | 15% |
Unknown | 24 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 25 | 27% |
Agricultural and Biological Sciences | 14 | 15% |
Immunology and Microbiology | 8 | 9% |
Medicine and Dentistry | 3 | 3% |
Neuroscience | 3 | 3% |
Other | 11 | 12% |
Unknown | 27 | 30% |