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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes
|
|---|---|
| Published in |
Frontiers in Chemistry, January 2013
|
| DOI | 10.3389/fchem.2013.00027 |
| Pubmed ID | |
| Authors |
Muhammad Hanif, Samuel M. Meier, Alexey A. Nazarov, Julie Risse, Anton Legin, Angela Casini, Michael A. Jakupec, Bernhard K. Keppler, Christian G. Hartinger |
| Abstract |
The synthesis and in vitro cytotoxicity of a series of Ru(II)(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohexylidene-protected carbohydrate is the most cytotoxic with unprecedented IC50 values for the compound class in three human cancer cell lines. This compound shows reactivity to the DNA model nucleobase 9-ethylguanine, but does not alter the secondary structure of plasmid DNA, indicating that other biological targets are responsible for its cytotoxic effect. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Russia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 24% |
| Student > Bachelor | 5 | 15% |
| Researcher | 3 | 9% |
| Student > Master | 3 | 9% |
| Professor | 3 | 9% |
| Other | 6 | 18% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 19 | 58% |
| Chemical Engineering | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Immunology and Microbiology | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2013.
All research outputs
#14,765,501
of 22,729,647 outputs
Outputs from Frontiers in Chemistry
#1,176
of 5,883 outputs
Outputs of similar age
#175,353
of 280,760 outputs
Outputs of similar age from Frontiers in Chemistry
#7
of 36 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,883 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,760 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.