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Mendeley readers
Attention Score in Context
| Title |
Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins
|
|---|---|
| Published in |
Frontiers in Chemistry, April 2014
|
| DOI | 10.3389/fchem.2014.00015 |
| Pubmed ID | |
| Authors |
Kim Wals, Huib Ovaa |
| Abstract |
Unnatural amino acid (UAA) incorporation by amber codon suppression offers scientists a powerful tool to modify the properties of proteins at will. UAA incorporation has been used for a plethora of fundamental research applications and, more recently, also for the selective modification of therapeutic proteins. In this review most recent developments in Escherichia coli codon expansion and, unnatural amino acid incorporation are discussed together with some remarkable recent developments in improved efficient UAA incorporation. We focus on the generation of proteins that hold promise for future therapeutic applications that would be impossible to obtain without unnatural amino acid incorporation, including the generation of bi-specific antibodies and antibody drug conjugates. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Scientists | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 671 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 666 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 186 | 28% |
| Student > Bachelor | 94 | 14% |
| Researcher | 83 | 12% |
| Student > Master | 78 | 12% |
| Student > Doctoral Student | 33 | 5% |
| Other | 62 | 9% |
| Unknown | 135 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 204 | 30% |
| Chemistry | 141 | 21% |
| Agricultural and Biological Sciences | 107 | 16% |
| Chemical Engineering | 16 | 2% |
| Engineering | 11 | 2% |
| Other | 44 | 7% |
| Unknown | 148 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 397. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#70,043
of 24,084,574 outputs
Outputs from Frontiers in Chemistry
#2
of 6,351 outputs
Outputs of similar age
#502
of 230,377 outputs
Outputs of similar age from Frontiers in Chemistry
#1
of 15 outputs
Altmetric has tracked 24,084,574 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,351 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,377 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.