Title |
Nanomedicines for cancer therapy: state-of-the-art and limitations to pre-clinical studies that hinder future developments
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Published in |
Frontiers in Chemistry, August 2014
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DOI | 10.3389/fchem.2014.00069 |
Pubmed ID | |
Authors |
Charlene M. Dawidczyk, Luisa M. Russell, Peter C. Searson |
Abstract |
The ability to efficiently deliver a drug or gene to a tumor site is dependent on a wide range of factors including circulation time, interactions with the mononuclear phagocyte system, extravasation from circulation at the tumor site, targeting strategy, release from the delivery vehicle, and uptake in cancer cells. Nanotechnology provides the possibility of creating delivery systems where the design constraints are decoupled, allowing new approaches for reducing the unwanted side effects of systemic delivery, increasing tumor accumulation, and improving efficacy. The physico-chemical properties of nanoparticle-based delivery platforms introduce additional complexity associated with pharmacokinetics, tumor accumulation, and biodistribution. To assess the impact of nanoparticle-based delivery systems, we first review the design strategies and pharmacokinetics of FDA-approved nanomedicines. Next we review nanomedicines under development, summarizing the range of nanoparticle platforms, strategies for targeting, and pharmacokinetics. We show how the lack of uniformity in preclinical trials prevents systematic comparison and hence limits advances in the field. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 1% |
United States | 2 | 1% |
Brazil | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Australia | 1 | <1% |
Unknown | 181 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 47 | 25% |
Student > Bachelor | 23 | 12% |
Student > Master | 22 | 12% |
Researcher | 18 | 10% |
Student > Postgraduate | 9 | 5% |
Other | 24 | 13% |
Unknown | 45 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 13% |
Chemistry | 23 | 12% |
Biochemistry, Genetics and Molecular Biology | 18 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 10% |
Medicine and Dentistry | 16 | 9% |
Other | 34 | 18% |
Unknown | 54 | 29% |