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Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon

Overview of attention for article published in Frontiers in Chemistry, August 2016
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Title
Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon
Published in
Frontiers in Chemistry, August 2016
DOI 10.3389/fchem.2016.00034
Pubmed ID
Authors

Amandine Kolleth, Julian Gebauer, Abdelatif ElMarrouni, Raphael Lebeuf, Céline Prévost, Eric Brohan, Stellios Arseniyadis, Janine Cossy

Abstract

We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 steps and 2% overall yield starting from commercially available 3-methyl-but-3-enol. Most importantly, the strategy employed is versatile enough to eventually allow us to complete the synthesis of the natural product and irrevocably confirm its structure.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 67%
Student > Bachelor 1 33%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 33%
Agricultural and Biological Sciences 1 33%
Psychology 1 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2016.
All research outputs
#15,381,002
of 22,882,389 outputs
Outputs from Frontiers in Chemistry
#1,586
of 5,968 outputs
Outputs of similar age
#233,708
of 361,775 outputs
Outputs of similar age from Frontiers in Chemistry
#7
of 11 outputs
Altmetric has tracked 22,882,389 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,968 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,775 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.