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Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells

Overview of attention for article published in Frontiers in Chemistry, April 2017
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Title
Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells
Published in
Frontiers in Chemistry, April 2017
DOI 10.3389/fchem.2017.00028
Pubmed ID
Authors

Elisabet Öberg, Hanna Appelqvist, K. Peter R. Nilsson

Abstract

Molecular tools for fluorescent imaging of specific compartments in cells are essential for understanding the function and activity of cells. Here, we report the synthesis of a series of pyridyl- and thienyl-substituted phospholes and the evaluation of these dyes for fluorescent imaging of cells. The thienyl-substituted phospholes proved to be successful for staining of cultured normal and malignant cells due to their fluorescent properties and low toxicity. Co-staining experiments demonstrated that these probes target lipid droplets, which are, lipid-storage organelles found in the cytosol of nearly all cell types. Our findings confirm that thienyl-substituted phospholes can be utilized as fluorescent tools for vital staining of cells, and we foresee that these fluorescent dyes might be used in studies to unravel the roles that lipid droplets play in cellular physiology and in diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 30%
Student > Postgraduate 2 20%
Professor 1 10%
Professor > Associate Professor 1 10%
Researcher 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Chemistry 5 50%
Physics and Astronomy 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Unknown 3 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2019.
All research outputs
#15,687,628
of 23,312,088 outputs
Outputs from Frontiers in Chemistry
#1,631
of 6,111 outputs
Outputs of similar age
#194,546
of 310,579 outputs
Outputs of similar age from Frontiers in Chemistry
#13
of 23 outputs
Altmetric has tracked 23,312,088 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,111 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,579 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.