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Analysis of Urine Composition in Type II Diabetic Mice after Intervention Therapy Using Holothurian Polypeptides

Overview of attention for article published in Frontiers in Chemistry, July 2017
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Title
Analysis of Urine Composition in Type II Diabetic Mice after Intervention Therapy Using Holothurian Polypeptides
Published in
Frontiers in Chemistry, July 2017
DOI 10.3389/fchem.2017.00054
Pubmed ID
Authors

Yanyan Li, Jiajie Xu, Xiurong Su

Abstract

Hydrolysates and peptide fractions (PF) obtained from sea cucumber with commercial enzyme were studied on the hyperglycemic and renal protective effects on db/db rats using urine metabolomics. Compared with the control group the polypeptides from the two species could significantly reduce the urine glucose and urea. We also tried to address the compositions of highly expressed urinary proteins using a proteomics approach. They were serum albumins, AMBP proteins, negative trypsin, elastase, and urinary protein, GAPDH, a receptor of urokinase-type plasminogen activator (uPAR), and Ig kappa chain C region. We used the electronic nose to quickly detect changes in the volatile substances in mice urine after holothurian polypeptides (HPP) fed, and the results show it can identify the difference between treatment groups with the control group without overlapping. The protein express mechanism of HPP treating diabetes was discussed, and we suggested these two peptides with the hypoglycemic and renal protective activity might be utilized as nutraceuticals.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Lecturer 2 10%
Professor 1 5%
Student > Bachelor 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 9 45%
Readers by discipline Count As %
Chemistry 3 15%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Environmental Science 1 5%
Immunology and Microbiology 1 5%
Other 3 15%
Unknown 10 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2017.
All research outputs
#20,438,227
of 22,992,311 outputs
Outputs from Frontiers in Chemistry
#2,932
of 6,005 outputs
Outputs of similar age
#276,793
of 317,089 outputs
Outputs of similar age from Frontiers in Chemistry
#18
of 28 outputs
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