Title |
Self-Assembly of a [1 + 1] Ionic Hexagonal Macrocycle and Its Antiproliferative Activity
|
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Published in |
Frontiers in Chemistry, April 2018
|
DOI | 10.3389/fchem.2018.00087 |
Pubmed ID | |
Authors |
Khushwant Singh, Ankit Gangrade, Sourav Bhowmick, Achintya Jana, Biman B. Mandal, Neeladri Das |
Abstract |
A unique irregular hexagon was self-assembled using an organic donor clip (bearing terminal pyridyl units) and a complementary organometallic acceptor clip. The resulting metallamacrocycle was characterized by multinuclear NMR, mass spectrometry, and elemental analyses. Molecular modeling confirmed hexagonal shaped cavity for this metallamacrocycle which is a unique example of a discrete hexagonal framework self-assembled from only two building blocks. Cytotoxicity of the Pt-based acceptor tecton and the self-assembled PtII-based macrocycle was evaluated using three cancer cell lines and results were compared with cisplatin. Results confirmed a positive effect of the metallamacrocycle formation on cell growth inhibition. |
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