Title |
Raman Spectroscopy for Pharmaceutical Quantitative Analysis by Low-Rank Estimation
|
---|---|
Published in |
Frontiers in Chemistry, September 2018
|
DOI | 10.3389/fchem.2018.00400 |
Pubmed ID | |
Authors |
Xiangyun Ma, Xueqing Sun, Huijie Wang, Yang Wang, Da Chen, Qifeng Li |
Abstract |
Raman spectroscopy has been widely used for quantitative analysis in biomedical and pharmaceutical applications. However, the signal-to-noise ratio (SNR) of Raman spectra is always poor due to weak Raman scattering. The noise in Raman spectral dataset will limit the accuracy of quantitative analysis. Because of high correlations in the spectral signatures, Raman spectra have the low-rank property, which can be used as a constraint to improve Raman spectral SNR. In this paper, a simple and feasible Raman spectroscopic analysis method by Low-Rank Estimation (LRE) is proposed. The Frank-Wolfe (FW) algorithm is applied in the LRE method to seek the optimal solution. The proposed method is used for the quantitative analysis of pharmaceutical mixtures. The accuracy and robustness of Partial Least Squares (PLS) and Support Vector Machine (SVM) chemometric models can be improved by the LRE method. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 19% |
Student > Bachelor | 5 | 16% |
Student > Master | 5 | 16% |
Researcher | 5 | 16% |
Student > Postgraduate | 2 | 6% |
Other | 0 | 0% |
Unknown | 9 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 4 | 13% |
Engineering | 3 | 9% |
Chemical Engineering | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 8 | 25% |
Unknown | 11 | 34% |