Title |
Leishmania promastigotes: building a safe niche within macrophages
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, January 2012
|
DOI | 10.3389/fcimb.2012.00121 |
Pubmed ID | |
Authors |
Neda Moradin, Albert Descoteaux |
Abstract |
Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 1% |
Brazil | 2 | <1% |
Australia | 1 | <1% |
Spain | 1 | <1% |
Unknown | 261 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 57 | 21% |
Student > Bachelor | 41 | 15% |
Student > Master | 38 | 14% |
Researcher | 23 | 9% |
Student > Doctoral Student | 14 | 5% |
Other | 30 | 11% |
Unknown | 66 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 80 | 30% |
Biochemistry, Genetics and Molecular Biology | 48 | 18% |
Immunology and Microbiology | 32 | 12% |
Medicine and Dentistry | 11 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
Other | 20 | 7% |
Unknown | 72 | 27% |