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Novel approaches to develop Rift Valley fever vaccines

Overview of attention for article published in Frontiers in Cellular and Infection Microbiology, January 2012
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68 Mendeley
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Title
Novel approaches to develop Rift Valley fever vaccines
Published in
Frontiers in Cellular and Infection Microbiology, January 2012
DOI 10.3389/fcimb.2012.00131
Pubmed ID
Authors

Sabarish V. Indran, Tetsuro Ikegami

Abstract

Rift Valley fever (RVF) is endemic to sub-Saharan Africa, and has spread into Madagascar, Egypt, Saudi Arabia, and Yemen. Rift Valley fever virus (RVFV) of the family Bunyaviridae, genus Phlebovirus causes hemorrhagic fever, neurological disorders or blindness in humans, and high rate abortion and fetal malformation in ruminants. RVFV is classified as a Category A Priority pathogen and overlap select agent by CDC/USDA due to its potential impact on public health and agriculture. There is a gap in the safety and immunogenicity in traditional RVF vaccines; the formalin-inactivated RVFV vaccine TSI-GSD-200 requires three doses for protection, and the live-attenuated Smithburn vaccine has a risk to cause abortion and fetal malformation in pregnant ruminants. In this review, problems of traditional vaccines and the safety and efficacy of recently reported novel RVF candidate vaccines including subunit vaccines, virus vector, and replicons are discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 1 1%
Unknown 67 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 21%
Student > Ph. D. Student 12 18%
Student > Master 10 15%
Student > Bachelor 4 6%
Professor > Associate Professor 3 4%
Other 5 7%
Unknown 20 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 22%
Medicine and Dentistry 9 13%
Veterinary Science and Veterinary Medicine 6 9%
Biochemistry, Genetics and Molecular Biology 5 7%
Social Sciences 4 6%
Other 12 18%
Unknown 17 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2012.
All research outputs
#13,872,372
of 22,679,690 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#2,368
of 6,291 outputs
Outputs of similar age
#151,733
of 244,102 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#56
of 109 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,291 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,102 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.