Title |
Mycobacterial signaling through toll-like receptors
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, January 2012
|
DOI | 10.3389/fcimb.2012.00145 |
Pubmed ID | |
Authors |
Joyoti Basu, Dong-Min Shin, Eun-Kyeong Jo |
Abstract |
Studies over the past decade have helped to decipher molecular networks dependent on Toll-like receptor (TLR) signaling, in mycobacteria-infected macrophages. Stimulation of TLRs by mycobacteria and their antigenic components rapidly induces intracellular signaling cascades involved in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways, which play important roles in orchestrating proinflammatory responses and innate defense through generation of a variety of antimicrobial effector molecules. Recent studies have provided evidence that mycobacterial TLR-signaling cross talks with other intracellular antimicrobial innate pathways, the autophagy process and functional vitamin D receptor (VDR) signaling. In this article we describe recent advances in the recognition, responses, and regulation of mycobacterial signaling through TLRs. |
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