You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, January 2013
|
| DOI | 10.3389/fcimb.2013.00028 |
| Pubmed ID | |
| Authors |
Suzana P. Salcedo, María I. Marchesini, Clara Degos, Matthieu Terwagne, Kristine Von Bargen, Hubert Lepidi, Claudia K. Herrmann, Thais L. Santos Lacerda, Paul R. C. Imbert, Philippe Pierre, Lena Alexopoulou, Jean-Jacques Letesson, Diego J. Comerci, Jean-Pierre Gorvel |
| Abstract |
Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 33% |
| France | 1 | 33% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | <1% |
| France | 1 | <1% |
| Peru | 1 | <1% |
| Unknown | 100 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 31% |
| Researcher | 21 | 20% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 7 | 7% |
| Other | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 11 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 32% |
| Immunology and Microbiology | 24 | 23% |
| Biochemistry, Genetics and Molecular Biology | 18 | 17% |
| Veterinary Science and Veterinary Medicine | 4 | 4% |
| Medicine and Dentistry | 2 | 2% |
| Other | 8 | 8% |
| Unknown | 14 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2013.
All research outputs
#14,755,210
of 22,713,403 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#3,128
of 6,309 outputs
Outputs of similar age
#175,323
of 280,747 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#46
of 92 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,747 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.