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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Manganese acquisition and homeostasis at the host-pathogen interface
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, January 2013
|
| DOI | 10.3389/fcimb.2013.00091 |
| Pubmed ID | |
| Authors |
John P. Lisher, David P. Giedroc |
| Abstract |
Pathogenic bacteria acquire transition metals for cell viability and persistence of infection in competition with host nutritional defenses. The human host employs a variety of mechanisms to stress the invading pathogen with both cytotoxic metal ions and oxidative and nitrosative insults while withholding essential transition metals from the bacterium. For example, the S100 family protein calprotectin (CP) found in neutrophils is a calcium-activated chelator of extracellular Mn and Zn and is found in tissue abscesses at sites of infection by Staphylococcus aureus. In an adaptive response, bacteria have evolved systems to acquire the metals in the face of this competition while effluxing excess or toxic metals to maintain a bioavailability of transition metals that is consistent with a particular inorganic "fingerprint" under the prevailing conditions. This review highlights recent biological, chemical and structural studies focused on manganese (Mn) acquisition and homeostasis and connects this process to oxidative stress resistance and iron (Fe) availability that operates at the human host-pathogen interface. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Sweden | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 125 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 26% |
| Researcher | 24 | 19% |
| Student > Master | 12 | 9% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 18 | 14% |
| Unknown | 23 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 23% |
| Biochemistry, Genetics and Molecular Biology | 28 | 22% |
| Chemistry | 19 | 15% |
| Immunology and Microbiology | 10 | 8% |
| Medicine and Dentistry | 6 | 5% |
| Other | 11 | 9% |
| Unknown | 25 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2015.
All research outputs
#12,840,433
of 22,758,248 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#1,803
of 6,348 outputs
Outputs of similar age
#152,303
of 280,897 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#39
of 92 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,348 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,897 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.