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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The use of resazurin as a novel antimicrobial agent against Francisella tularensis
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, January 2013
|
| DOI | 10.3389/fcimb.2013.00093 |
| Pubmed ID | |
| Authors |
Deanna M. Schmitt, Dawn M. O'Dee, Brianna N. Cowan, James W.-M. Birch, Leanne K. Mazzella, Gerard J. Nau, Joseph Horzempa |
| Abstract |
The highly infectious and deadly pathogen, Francisella tularensis, is classified by the CDC as a Category A bioterrorism agent. Inhalation of a single bacterium results in an acute pneumonia with a 30-60% mortality rate without treatment. Due to the prevalence of antibiotic resistance, there is a strong need for new types of antibacterial drugs. Resazurin is commonly used to measure bacterial and eukaryotic cell viability through its reduction to the fluorescent product resorufin. When tested on various bacterial taxa at the recommended concentration of 44 μM, a potent bactericidal effect was observed against various Francisella and Neisseria species, including the human pathogens type A F. tularensis (Schu S4) and N. gonorrhoeae. As low as 4.4 μM resazurin was sufficient for a 10-fold reduction in F. tularensis growth. In broth culture, resazurin was reduced to resorufin by F. tularensis. Resorufin also suppressed the growth of F. tularensis suggesting that this compound is the biologically active form responsible for decreasing the viability of F. tularensis LVS bacteria. Replication of F. tularensis in primary human macrophages and non-phagocytic cells was abolished following treatment with 44 μM resazurin indicating this compound could be an effective therapy for tularemia in vivo. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 24 | 24% |
| Student > Ph. D. Student | 13 | 13% |
| Student > Master | 13 | 13% |
| Researcher | 7 | 7% |
| Other | 6 | 6% |
| Other | 15 | 15% |
| Unknown | 21 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 25% |
| Agricultural and Biological Sciences | 13 | 13% |
| Immunology and Microbiology | 11 | 11% |
| Medicine and Dentistry | 7 | 7% |
| Chemistry | 7 | 7% |
| Other | 12 | 12% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2013.
All research outputs
#12,770,205
of 22,731,677 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#1,794
of 6,325 outputs
Outputs of similar age
#151,615
of 280,774 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#38
of 92 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,325 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,774 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.