Title |
Shifting the paradigm from pathogens to pathobiome: new concepts in the light of meta-omics
|
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Published in |
Frontiers in Cellular and Infection Microbiology, March 2014
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DOI | 10.3389/fcimb.2014.00029 |
Pubmed ID | |
Authors |
Muriel Vayssier-Taussat, Emmanuel Albina, Christine Citti, Jean-Franҫois Cosson, Marie-Agnès Jacques, Marc-Henri Lebrun, Yves Le Loir, Mylène Ogliastro, Marie-Agnès Petit, Philippe Roumagnac, Thierry Candresse |
Abstract |
The concept of pathogenesis has evolved considerably over recent years, and the scenario "a microbe + virulence factors = disease" is probably far from reality in a number of cases. Actual pathogens have extremely broad biological diversity and are found in all major groups of microorganisms (viruses, bacteria, fungi, protozoa…). Their pathogenicity results from strong and often highly specific interactions they have with either their microbial environment, hosts and/or arthropod vectors. In this review, we explore the contribution of metagenomic approaches toward understanding pathogens within the context of microbial communities. With this broader view, we discussed the concept of "pathobiome" and the research questions that this raises. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 25% |
France | 3 | 11% |
Spain | 2 | 7% |
Canada | 2 | 7% |
United Kingdom | 2 | 7% |
Italy | 1 | 4% |
Australia | 1 | 4% |
Peru | 1 | 4% |
Paraguay | 1 | 4% |
Other | 0 | 0% |
Unknown | 8 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 50% |
Scientists | 10 | 36% |
Science communicators (journalists, bloggers, editors) | 2 | 7% |
Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | <1% |
United States | 3 | <1% |
France | 2 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
India | 1 | <1% |
Korea, Republic of | 1 | <1% |
Egypt | 1 | <1% |
Unknown | 431 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 98 | 22% |
Researcher | 90 | 20% |
Student > Master | 47 | 11% |
Student > Bachelor | 30 | 7% |
Professor | 25 | 6% |
Other | 79 | 18% |
Unknown | 75 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 193 | 43% |
Biochemistry, Genetics and Molecular Biology | 45 | 10% |
Medicine and Dentistry | 27 | 6% |
Environmental Science | 20 | 5% |
Immunology and Microbiology | 17 | 4% |
Other | 45 | 10% |
Unknown | 97 | 22% |