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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Methicillin resistance and the biofilm phenotype in Staphylococcus aureus
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, January 2015
|
| DOI | 10.3389/fcimb.2015.00001 |
| Pubmed ID | |
| Authors |
Hannah McCarthy, Justine K. Rudkin, Nikki S. Black, Laura Gallagher, Eoghan O'Neill, James P. O'Gara |
| Abstract |
Antibiotic resistance and biofilm-forming capacity contribute to the success of Staphylococcus aureus as a human pathogen in both healthcare and community settings. These virulence factors do not function independently of each other and the biofilm phenotype expressed by clinical isolates of S. aureus is influenced by acquisition of the methicillin resistance gene mecA. Methicillin-sensitive S. aureus (MSSA) strains commonly produce an icaADBC operon-encoded polysaccharide intercellular adhesin (PIA)-dependent biofilm. In contrast, the release of extracellular DNA (eDNA) and cell surface expression of a number of sortase-anchored proteins, and the major autolysin have been implicated in the biofilm phenotype of methicillin-resistant S. aureus (MRSA) isolates. Expression of high level methicillin resistance in a laboratory MSSA strain resulted in (i) repression of PIA-mediated biofilm production, (ii) down-regulation of the accessory gene regulator (Agr) system, and (iii) attenuation of virulence in murine sepsis and device infection models. Here we review the mechanisms of MSSA and MRSA biofilm production and the relationships between antibiotic resistance, biofilm and virulence gene regulation in S. aureus. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 516 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| India | 1 | <1% |
| Kenya | 1 | <1% |
| Denmark | 1 | <1% |
| Sri Lanka | 1 | <1% |
| Unknown | 510 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 86 | 17% |
| Student > Ph. D. Student | 79 | 15% |
| Student > Master | 74 | 14% |
| Researcher | 47 | 9% |
| Student > Doctoral Student | 29 | 6% |
| Other | 71 | 14% |
| Unknown | 130 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 103 | 20% |
| Immunology and Microbiology | 86 | 17% |
| Biochemistry, Genetics and Molecular Biology | 75 | 15% |
| Medicine and Dentistry | 47 | 9% |
| Chemistry | 13 | 3% |
| Other | 44 | 9% |
| Unknown | 148 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2022.
All research outputs
#2,266,215
of 23,842,189 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#380
of 7,064 outputs
Outputs of similar age
#33,039
of 357,595 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#4
of 49 outputs
Altmetric has tracked 23,842,189 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,064 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.