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Genetic characterization of Shiga toxin-producing Escherichia coli O26:H11 strains isolated from animal, food, and clinical samples

Overview of attention for article published in Frontiers in Cellular and Infection Microbiology, October 2015
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Title
Genetic characterization of Shiga toxin-producing Escherichia coli O26:H11 strains isolated from animal, food, and clinical samples
Published in
Frontiers in Cellular and Infection Microbiology, October 2015
DOI 10.3389/fcimb.2015.00074
Pubmed ID
Authors

Alejandra Krüger, Paula M. A. Lucchesi, A. Mariel Sanso, Analía I. Etcheverría, Ana V. Bustamante, Julia Burgán, Luciana Fernández, Daniel Fernández, Gerardo Leotta, Alexander W. Friedrich, Nora L. Padola, John W. A. Rossen

Abstract

The Shiga-toxin producing Escherichia coli (STEC) may cause serious illness in human. Here we analyze O26:H11 strains known to be among the most reported STEC strains causing human infections. Genetic characterization of strains isolated from animal, food, and clinical specimens in Argentina showed that most carried either stx 1a or stx 2a subtypes. Interestingly, stx 2a-positive O26:H11 rarely isolated from cattle in other countries showed to be an important proportion of O26:H11 strains circulating in cattle and food in our region. Seventeen percent of the isolates harbored more than one gene associated with antimicrobial resistance. In addition to stx, all strains contained the virulence genes eae-β, tir, efa, iha, espB, cif, espA, espF, espJ, nleA, nleB, nleC, and iss; and all except one contained ehxA, espP, and cba genes. On the other hand, toxB and espI genes were exclusively observed in stx 2-positive isolates, whereas katP was only found in stx 1a-positive isolates. Our results show that O26:H11 STEC strains circulating in Argentina, including those isolated from humans, cattle, and meat products, present a high pathogenic potential, and evidence that cattle can be a reservoir of O26:H11 strains harboring stx 2a.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 17%
Student > Ph. D. Student 10 17%
Student > Master 8 14%
Student > Doctoral Student 5 8%
Professor 3 5%
Other 9 15%
Unknown 14 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 15%
Agricultural and Biological Sciences 8 14%
Immunology and Microbiology 7 12%
Medicine and Dentistry 4 7%
Chemistry 3 5%
Other 8 14%
Unknown 20 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2016.
All research outputs
#20,519,463
of 25,217,627 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#5,944
of 7,943 outputs
Outputs of similar age
#212,397
of 290,129 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#19
of 24 outputs
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