Title |
Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, November 2015
|
DOI | 10.3389/fcimb.2015.00077 |
Pubmed ID | |
Authors |
Nianshuang Li, Chuan Xie, Nong-Hua Lu |
Abstract |
Helicobacter pylori (H.pylori) is a Gram-negative, microaerophilic, helical bacillus that specifically colonizes the gastric mucosa. The interaction of virulence factors, host genetic factors, and environmental factors contributes to the pathogenesis of H. pylori-associated conditions, such as atrophic gastritis and intestinal metaplasia. Infection with H. pylori has recently been recognized as the strongest risk factor for gastric cancer. As a pleiotropic cytokine, transforming growth factor (TGF)-β regulates various biological processes, including cell cycle, proliferation, apoptosis, and metastasis. Recent studies have shed new light on the involvement of TGF-β signaling in the pathogenesis of H. pylori infection. This review focuses on the potential etiological roles of TGF-β in H. pylori-mediated gastric pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Thailand | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Student > Master | 9 | 17% |
Student > Bachelor | 6 | 12% |
Student > Doctoral Student | 4 | 8% |
Lecturer | 4 | 8% |
Other | 11 | 21% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 25% |
Agricultural and Biological Sciences | 12 | 23% |
Medicine and Dentistry | 11 | 21% |
Immunology and Microbiology | 4 | 8% |
Mathematics | 1 | 2% |
Other | 2 | 4% |
Unknown | 9 | 17% |