Title |
New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
|
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Published in |
Frontiers in Cellular and Infection Microbiology, January 2016
|
DOI | 10.3389/fcimb.2015.00103 |
Pubmed ID | |
Authors |
Leandro S. Silva, João Luiz Silva-Filho, Celso Caruso-Neves, Ana Acacia S. Pinheiro |
Abstract |
Malaria is a worldwide health problem leading the death of millions of people. The disease is induced by different species of protozoa parasites from the genus Plasmodium. In humans, Plasmodium falciparum is the most dangerous species responsible for severe disease. Despite all efforts to establish the pathogenesis of malaria, it is far from being fully understood. In addition, resistance to existing drugs has developed in several strains and the development of new effective compounds to fight these parasites is a major issue. Recent discoveries indicate the potential role of the renin-angiotensin system (RAS) in malaria infection. Angiotensin receptors have not been described in the parasite genome, however several reports in the literature suggest a direct effect of angiotensin-derived peptides on different aspects of the host-parasite interaction. The aim of this review is to highlight new findings on the involvement of the RAS in parasite development and in the regulation of the host immune response in an attempt to expand our knowledge of the pathogenesis of this disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 13 | 15% |
Canada | 3 | 4% |
United Kingdom | 1 | 1% |
Ireland | 1 | 1% |
South Africa | 1 | 1% |
Spain | 1 | 1% |
Austria | 1 | 1% |
Belgium | 1 | 1% |
Korea, Republic of | 1 | 1% |
Other | 4 | 5% |
Unknown | 57 | 68% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 77 | 92% |
Scientists | 5 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Nigeria | 1 | 1% |
Canada | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 71 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 19% |
Student > Ph. D. Student | 9 | 12% |
Student > Doctoral Student | 8 | 11% |
Student > Bachelor | 8 | 11% |
Student > Master | 8 | 11% |
Other | 15 | 20% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 31% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Agricultural and Biological Sciences | 9 | 12% |
Immunology and Microbiology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 3 | 4% |
Unknown | 18 | 24% |