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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identification and Characterization of Staphylococcus aureus Strains with an Incomplete Hemolytic Phenotype
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, November 2016
|
| DOI | 10.3389/fcimb.2016.00146 |
| Pubmed ID | |
| Authors |
Haifang Zhang, Yi Zheng, Huasheng Gao, Ping Xu, Min Wang, Aiqing Li, Minhui Miao, Xiaofang Xie, Yimai Deng, Huiqin Zhou, Hong Du |
| Abstract |
Staphylococcus aureus is a common pathogen causing both hospital and community-acquired infections. Hemolysin is one of the important virulence factors for S. aureus and causes the typical β-hemolytic phenotype which is called complete hemolytic phenotype as well. Recently, S. aureus with an incomplete hemolytic phenotype (SIHP) was isolated from clinical samples. To study the microbiologic characteristics of SIHP, the special hemolytic phenotype of SIHP was verified on the sheep blood agar plates supplied by different manufacturers. Expression of hemolysin genes hla, hlb, hlgC, and hld of SIHP was detected by qRT-PCR and it was showed that expression of hlb in SIHP was obviously increased compared to the control S. aureus strains with complete hemolytic phenotype (SCHP), while the expression of hla, hlgC, and hld in SIHP was significantly decreased. In addition, the α-hemolysin encoded by gene hla was decreased obviously in SIHP compared to SCHP by western blot. All 60 SIHP strains were identified to be the methicillin resistant S. aureus (MRSA), and moreover these SIHP strains all contains mecA gene. The virulence gene tst were all present in SIHP, and the intracellular survival ability of SIHP was much greater than that of the gene tst negative S. aureus. We also found that IL-2, IL-6, and IL-17A secreted in the supernatant of SIHP infected macrophages increased significantly compared to tst negative control strains infected ones. MLST analysis showed that all of SIHP strains were classified into ST5 clone. To our knowledge, this study firstly showed that SIHP strains are a kind of methicillin resistant strains which express β-hemolysin highly and possess a potential high virulence, and it was suggested that SIHP should be paid more attention in hospital. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Spain | 1 | 17% |
| Switzerland | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 83% |
| Members of the public | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 177 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 37 | 21% |
| Student > Master | 15 | 8% |
| Student > Ph. D. Student | 12 | 7% |
| Researcher | 11 | 6% |
| Other | 4 | 2% |
| Other | 16 | 9% |
| Unknown | 82 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 16% |
| Immunology and Microbiology | 19 | 11% |
| Agricultural and Biological Sciences | 18 | 10% |
| Veterinary Science and Veterinary Medicine | 9 | 5% |
| Medicine and Dentistry | 6 | 3% |
| Other | 12 | 7% |
| Unknown | 84 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2019.
All research outputs
#13,997,995
of 24,410,160 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#2,159
of 7,449 outputs
Outputs of similar age
#206,391
of 424,492 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#14
of 66 outputs
Altmetric has tracked 24,410,160 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,449 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,492 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.