Title |
P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, March 2017
|
DOI | 10.3389/fcimb.2017.00081 |
Pubmed ID | |
Authors |
Joerg R. Leheste, Kathryn E. Ruvolo, Joanna E. Chrostowski, Kristin Rivera, Christopher Husko, Alyssa Miceli, Martin K. Selig, Holger Brüggemann, German Torres |
Abstract |
This review discusses the biology and behavior of Propionibacterium acnes (P. acnes), a dominant bacterium species of the skin biogeography thought to be associated with transmission, recurrence and severity of disease. More specifically, we discuss the ability of P. acnes to invade and persist in epithelial cells and circulating macrophages to subsequently induce bouts of sarcoidosis, low-grade inflammation and metastatic cell growth in the prostate gland. Finally, we discuss the possibility of P. acnes infiltrating the brain parenchyma to indirectly contribute to pathogenic processes in neurodegenerative disorders such as those observed in Parkinson's disease (PD). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 33% |
Colombia | 1 | 33% |
Switzerland | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 125 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 10% |
Researcher | 12 | 10% |
Other | 9 | 7% |
Student > Master | 8 | 6% |
Student > Bachelor | 7 | 6% |
Other | 20 | 16% |
Unknown | 57 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 17% |
Immunology and Microbiology | 12 | 10% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Agricultural and Biological Sciences | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 13 | 10% |
Unknown | 61 | 49% |