Title |
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection
|
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Published in |
Frontiers in Cellular and Infection Microbiology, May 2017
|
DOI | 10.3389/fcimb.2017.00169 |
Pubmed ID | |
Authors |
Liu Chunfa, Sun Xin, Li Qiang, Srinand Sreevatsan, Lifeng Yang, Deming Zhao, Xiangmei Zhou |
Abstract |
Mycobacterium bovis (M. bovis) is the pathogen of animals and humans that can replicate in the phagosomes of myeloid cells. Cytosolic detection of bacterial products plays a crucial role in initiating the innate immune response, including autophagy activation and interferon-β (IFN-β) release. Although IFN-β release and autophagy activation have been reported during mycobacterium infection, the mechanisms underlying remains poorly defined. Here, we demonstrated that IFN-β release increases in macrophages exposed to M. bovis and this requires the activation of the DNA sensor of interferon-γ inducible protein 204 (IFI204). Knockdown of the IFI204 in immortalized and primary murine macrophages blocked IFN-β production and autophagy marker LC3 expression. Thus, our results indicate that the IFI204 is an important sensor for innate immune responses of M. bovis infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 29% |
Researcher | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Unspecified | 1 | 3% |
Other | 1 | 3% |
Other | 2 | 6% |
Unknown | 12 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 7 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Veterinary Science and Veterinary Medicine | 4 | 13% |
Agricultural and Biological Sciences | 1 | 3% |
Unspecified | 1 | 3% |
Other | 2 | 6% |
Unknown | 11 | 35% |