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Bioluminescence Imaging to Track Bacteroides fragilis Inhibition of Vibrio parahaemolyticus Infection in Mice

Overview of attention for article published in Frontiers in Cellular and Infection Microbiology, May 2017
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Title
Bioluminescence Imaging to Track Bacteroides fragilis Inhibition of Vibrio parahaemolyticus Infection in Mice
Published in
Frontiers in Cellular and Infection Microbiology, May 2017
DOI 10.3389/fcimb.2017.00170
Pubmed ID
Authors

Zhengchao Li, Huimin Deng, Yazhou Zhou, Yafang Tan, Xiaoyi Wang, Yanping Han, Yangyang Liu, Ye Wang, Ruifu Yang, Yujing Bi, Fachao Zhi

Abstract

Bacteroides fragilis is an anaerobic, Gram-negative, commensal bacterium of the human gut. It plays an important role in promoting the maturation of the immune system, as well as suppressing abnormal inflammation. Many recent studies have focused on the relationship between B. fragilis and human immunity, and indicate that B. fragilis has many useful probiotic effects. As inhibition of intestinal pathogens is an important characteristic of probiotic strains, this study examined whether B. fragilis could inhibit pathogenic bacteria. Results showed that Vibrio parahaemolyticus was inhibited by B. fragilis in vitro, and that B. fragilis could protect both RAW 264.7 and LoVo cells from damage caused by V. parahaemolyticus. Using in vivo imaging, we constructed a light-emitting V. parahaemolyticus strain and showed that B. fragilis might shorten the colonization time and reduce the number of lux-expressing bacteria in a mouse model. These results provide useful information for developing B. fragilis into a probiotic product, and also indicate that this commensal bacterium might aid in the clinical treatment of gastroenteritis caused by V. parahaemolyticus.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 22%
Student > Ph. D. Student 7 15%
Student > Bachelor 4 9%
Researcher 4 9%
Student > Postgraduate 3 7%
Other 5 11%
Unknown 13 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 26%
Agricultural and Biological Sciences 10 22%
Immunology and Microbiology 8 17%
Veterinary Science and Veterinary Medicine 1 2%
Environmental Science 1 2%
Other 0 0%
Unknown 14 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2017.
All research outputs
#15,407,037
of 22,971,207 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#3,577
of 6,471 outputs
Outputs of similar age
#194,443
of 310,860 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#119
of 183 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,471 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,860 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 183 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.