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IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis

Overview of attention for article published in Frontiers in Cellular and Infection Microbiology, May 2017
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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Title
IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis
Published in
Frontiers in Cellular and Infection Microbiology, May 2017
DOI 10.3389/fcimb.2017.00200
Pubmed ID
Authors

Ana V. Ibarra-Meneses, Prakash Ghosh, Faria Hossain, Rajashree Chowdhury, Dinesh Mondal, Jorge Alvar, Javier Moreno, Eugenia Carrillo

Abstract

New biomarkers are needed for monitoring the effectiveness of treatment for visceral leishmaniasis (VL). They might also improve the detection of the asymptomatic population in Leishmania-endemic areas. This paper examines the IL-2, IFN-γ, IFN-γ-induced protein 10 (IP-10), and monokine-induced-by-IFN-γ (MIG) levels in whole blood-stimulated in vitro with soluble Leishmania antigen (SLA)-taken from asymptomatic individuals and patients treated for VL living in a post-outbreak (Leishmania infantum) area in Spain, and in an endemic (Leishmania donovani) area of Bangladesh. IP-10 was found to be an accurate global marker of asymptomatic subjects with positive cellular/humoral tests, while MIG was found to be a better marker of contact with L. donovani than IL-2 but no for those with L. infantum. Determining IP-10, MIG, and IFN-γ levels proved useful in monitoring the cellular immune response following treatment for active disease caused by L. infantum.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 20%
Student > Ph. D. Student 12 14%
Student > Bachelor 9 10%
Student > Master 9 10%
Student > Doctoral Student 8 9%
Other 10 12%
Unknown 21 24%
Readers by discipline Count As %
Immunology and Microbiology 13 15%
Medicine and Dentistry 13 15%
Agricultural and Biological Sciences 13 15%
Biochemistry, Genetics and Molecular Biology 11 13%
Veterinary Science and Veterinary Medicine 4 5%
Other 9 10%
Unknown 23 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2018.
All research outputs
#6,050,381
of 22,977,819 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#1,106
of 6,474 outputs
Outputs of similar age
#96,281
of 316,427 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#45
of 190 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 6,474 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 190 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.