Title |
Metabolic Adaptations of Uropathogenic E. coli in the Urinary Tract
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, June 2017
|
DOI | 10.3389/fcimb.2017.00241 |
Pubmed ID | |
Authors |
Riti Mann, Daniel G. Mediati, Iain G. Duggin, Elizabeth J. Harry, Amy L. Bottomley |
Abstract |
Escherichia coli ordinarily resides in the lower gastrointestinal tract in humans, but some strains, known as Uropathogenic E. coli (UPEC), are also adapted to the relatively harsh environment of the urinary tract. Infections of the urine, bladder and kidneys by UPEC may lead to potentially fatal bloodstream infections. To survive this range of conditions, UPEC strains must have broad and flexible metabolic capabilities and efficiently utilize scarce essential nutrients. Whole-organism (or "omics") methods have recently provided significant advances in our understanding of the importance of metabolic adaptation in the success of UPECs. Here we describe the nutritional and metabolic requirements for UPEC infection in these environments, and focus on particular metabolic responses and adaptations of UPEC that appear to be essential for survival in the urinary tract. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 7 | 41% |
Switzerland | 3 | 18% |
Singapore | 2 | 12% |
United States | 2 | 12% |
Netherlands | 1 | 6% |
United Kingdom | 1 | 6% |
Chile | 1 | 6% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 10 | 59% |
Members of the public | 5 | 29% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Unknown | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 295 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 17% |
Student > Master | 41 | 14% |
Student > Bachelor | 41 | 14% |
Researcher | 28 | 9% |
Other | 11 | 4% |
Other | 33 | 11% |
Unknown | 91 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 50 | 17% |
Immunology and Microbiology | 44 | 15% |
Agricultural and Biological Sciences | 26 | 9% |
Medicine and Dentistry | 21 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 3% |
Other | 49 | 17% |
Unknown | 96 | 33% |