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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, August 2017
|
| DOI | 10.3389/fcimb.2017.00367 |
| Pubmed ID | |
| Authors |
Gisela Canedo-Marroquín, Orlando Acevedo-Acevedo, Emma Rey-Jurado, Juan M. Saavedra, Margarita K. Lay, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis |
| Abstract |
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide. Symptoms of hRSV infection include bronchiolitis and pneumonia. The lung pathology observed during hRSV infection is due in part to an exacerbated host immune response, characterized by immune cell infiltration to the lungs. HRSV is an enveloped virus, a member of the Pneumoviridae family, with a non-segmented genome and negative polarity-single RNA that contains 10 genes encoding for 11 proteins. These include the Fusion protein (F), the Glycoprotein (G), and the Small Hydrophobic (SH) protein, which are located on the virus surface. In addition, the Nucleoprotein (N), Phosphoprotein (P) large polymerase protein (L) part of the RNA-dependent RNA polymerase complex, the M2-1 protein as a transcription elongation factor, the M2-2 protein as a regulator of viral transcription and (M) protein all of which locate inside the virion. Apart from the structural proteins, the hRSV genome encodes for the non-structural 1 and 2 proteins (NS1 and NS2). HRSV has developed different strategies to evade the host immunity by means of the function of some of these proteins that work as virulence factors to improve the infection in the lung tissue. Also, hRSV NS-1 and NS-2 proteins have been shown to inhibit the activation of the type I interferon response. Furthermore, the hRSV nucleoprotein has been shown to inhibit the immunological synapsis between the dendritic cells and T cells during infection, resulting in an inefficient T cell activation. Here, we discuss the hRSV virulence factors and the host immunological features raised during infection with this virus. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 14% |
| United Kingdom | 1 | 14% |
| Australia | 1 | 14% |
| Switzerland | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Scientists | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 18% |
| Student > Bachelor | 15 | 15% |
| Researcher | 13 | 13% |
| Student > Doctoral Student | 8 | 8% |
| Student > Master | 7 | 7% |
| Other | 17 | 17% |
| Unknown | 24 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 22 | 22% |
| Biochemistry, Genetics and Molecular Biology | 18 | 18% |
| Medicine and Dentistry | 18 | 18% |
| Agricultural and Biological Sciences | 11 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 5 | 5% |
| Unknown | 25 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2022.
All research outputs
#7,402,040
of 23,299,593 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#1,589
of 6,674 outputs
Outputs of similar age
#106,093
of 288,420 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#31
of 124 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 6,674 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.